| Group | Club/Team Name | Team ID | Head Coach |
| D21 | Mt. Pleasant SC - 01 MPRD Springers U12G |
03007-001RG2U-0008 | Kevin McNamara |
| D22 | James Island Youth SC JIYSC 2011 Girls Black Ryan |
03001-001AG2U-1138 | Ryan Hedley |
| D23 | Cainhoy Athletic Soccer Club CASC 11 Riptides Grey |
03006-001AG2U-2334 | Gabriela Acosta |
| D24 | Tormenta FC Academy - 01 TFC 12G Ibis |
03035-001AG2U-0015 | Kian Brownlee |
| D25 | Tormenta FC Academy - 01 TFC 11G Statesboro |
03035-001RG2U-0016 | Ayomikun Fajemisin |
| D26 | Bluffton Rush Soccer Club - 01 Bluffton Rush 2011 Girls |
03040-001AG2U-0037 | Richard Reynolds |